- Tom Hanks
- Robert Langdon
- Ewan McGregor
- Camerlengo Patrick McKenna
- Ayelet Zurer
- Vittoria Vetra
- Armin Mueller-Stahl
- Cardinal Strauss
- Stellan Skarsgård
- Richter
- Pierfrancesco Favino
- Inspector Olivetti
- Nikolaj Lie Kaas
- Assassin
- Thure Lindhardt
- Chartrand
- David Pasquesi
- Claudio Vincenzi
- Cosimo Fusco
- Father Simeon
- Victor Alfieri
- Lt. Valenti
- Franklin Amobi
- Cardinal Lamasse
- Curt Lowens
- Cardinal Ebner
- Bob Yerkes
- Cardinal Guidera
- Marc Fiorini
- Cardinal Baggia
- Carmen Argenziano
- Silvano Bentivoglio
- Howard Mungo
- Cardinal Yoruba
- Rance Howard
- Cardinal Beck
- Ron Howard
- Director
- Akiva Goldsman
- Screenwriter
- David Koepp
- Screenwriter
- Brian Grazer
- Producer
- John Calley
- Producer
- Todd Hallowell
- Executive Producer
- Dan Brown
- Executive Producer
- Salvatore Totino
- Cinematographer
- Dan Hanley
- Film Editing
- Mike Hill
- Film Editing
- Hans Zimmer
- Original Music
- Allan Cameron
- Production Design
- Alex Cameron
- Art Director
- Keith P. Cunningham
- Art Director
- Luke Freeborn
- Art Director
- Marc Homes
- Art Director
- Giles Masters
- Art Director
- Dawn Swiderski
- Art Director
- Robert Gould
- Set Decoration
- Larry Bellantoni
- Set Decoration
- Daniel Orlandi
- Costume Design
- Lene Seested
- Casting
- Debbie McWilliams
- Casting
- Béatrice Kruger
- Casting
- Michelle Lewitt
- Casting
- Janet Hirshenson
- Casting
- Jane Jenkins
- Casting
- Marco Valerio Pugini
- Executive Producer
