Chicago Sun-Times

By Roger Ebert
The movie never says so, but it's a practical parable about the debate between pro-choice and pro-life. If you're pro-life, you would require Anna to donate her kidney, although there is a chance she could die, and her sister doesn't have a good prognosis. If you're pro-choice, you would support Anna's lawsuit.
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Wall Street Journal

By Joe Morgenstern
For all its awkward structure, the film is heartfelt and deeply affecting.
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The Hollywood Reporter

By Kirk Honeycutt
If you're going to make a weepy, there's no reason you can't make it with intelligence and insight as the makers of My Sister's Keeper have done.
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Philadelphia Inquirer

By Steven Rea
Diaz gets her own voice-over monologue, as does Patric - the different points of view functioning like stanza refrains, born in shared familial anguish.
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Entertainment Weekly

By Lisa Schwarzbaum
Their message (Cassavetes and screenwriter Jeremy Leven) in My Sister's Keeper? Cancer sucks, but there's always the balm of beach scenes and an emo soundtrack.
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Boston Globe

By Ty Burr
A pall of disaster, in fact, hangs over everyone in this shapeless, hankie-wringing adaptation of the best-selling Jodi Picoult novel.
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USA Today

By Claudia Puig
Abigail Breslin and Sofia Vassilieva are terrific. But the performances by the older actors are largely forgettable.
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New York Daily News

By Joe Neumaier
Patric and Baldwin react to all the morbidity with restraint, and Vassilieva keeps her bald head high. But they won't be able to help this barefaced vulgarity earn any terms of endearment.
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Rolling Stone

By Peter Travers
The infuriating cop–out ending reduces the premise to mush. I wanted to scream. Here goes: Arghh!
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San Francisco Chronicle

By Mick LaSalle
Has a gutsy premise, but no guts.
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51 out of 100
Mixed or average reviews
Metascore® based on all critic reviews. Scores range from 0 to 100, with higher scores indicating more favorable reviews.