Grey's Anatomy's Dr. Izzie Stevens (Katherine Heigl) tackles the romantic comedy genre again this summer in The Ugly Truth alongside 300 hunk, Gerard Butler. Her biggest movie breakout was in Knocked Up in 2007 and then 27 Dresses in 2008.
By John Halecky
Anyone remember a little TV show called Alias? Cooper played Will Tippin in the series as well as Jack Bourdain in Kitchen Confidential before starring as Phil in the summer's monster hit The Hangover.
Before he was getting his tooth knocked out or marrying a stripper played by Heather Graham in The Hangover, Ed Helms started out on The Daily Show as a correspondant before moving onto The Office with fellow Daily Show alum, Steve Carell.
Cutting her teeth on the soaps One Life to Live and Guiding Light helped prepare Panettiere for her most well-known role as Claire Bennet, the infamous cheerleader on the TV series Heroes. She can be seen on the big screen in this summer's teen comedy I Love You, Beth Cooper.
After playing alien Tommy Solomon on 3rd Rock from the Sun for years, Gordon-Levitt has been starring in a number of movies including Mysterious Skin, Brick and The Lookout. This summer, he's in two movies, (500) Days of Summer and G.I. Joe: The Rise of Cobra.
Krasinski takes a break from playing Jim from The Office by growing a scraggly beard and wearing glasses as Burt in the quirky indie Away We Go.
SNL alum Rudolph is the latest cast member to make the jump to the big screen from the weekly show in Away We Go, alongside fellow TV to Movie star, John Krasinski.
Although it only aired for one season, the well reviewed cop drama The Unusuals was the TV home for Renner before starring in the Kathryn Bigelow directed feature, The Hurt Locker.
Kvetching Larry David doesn't stretch too far from his Curb Your Enthusiasm character as Boris Yellnikoff in Woody Allen's latest comedy, Whatever Works.
Gilmore Girl Lorelai (Lauren Graham) stars alongside Jeff Daniels in the romantic comedy, The Answer Man. Graham previously was in Bad Santa (2003), The Pacifier (2005) and Evan Almighty (2007) at your local multiplex.
Before he became a go-to comedy guy for the big screen in movies like Year One, Superbad and Juno, Cera starred in the much loved TV series Arrested Development, which is still rumored to be made into a movie with Cera reprising his role as George-Michael Bluth.
Way, way, way before Mr. Scarlett Johansson starred in this summer's Wolverine or The Proposal, he was slinging pizzas in the comdey series, Two Guys, a Girl and a Pizza Place. Next up for Reynolds is the the big screen actioner Deadpool and the newly announced Green Lantern.
Everybody Loves Raymond star Romano is back for the third installment of the animated hit Ice Age series of movies, Ice Age: Dawn of the Dinosaurs voicing the lovable loser Manny the wooly mammoth.
While he's best known for playing super-agent Ari Gold on HBO's Entourage, Piven also makes the leap to the big screen from time to time in movies like The Kingdom, Smokin' Aces and his latest, The Goods: Live Hard, Sell Hard.
Making her TV acting debut as Rory in Gilmore Girls, Bledel has gone on to act in movies such as Sin City, The Sisterhood of the Traveling Pants and this summer's Post Grad.
Comedian Martin is another Daily Show alum to make the transition to the silver screen in this summer's Taking Woodstock. He also has a comedy TV series appropriately titled, Important Things with Demetri Martin.