By James Berardinelli
The result, bolstered by strong acting and an intriguing back story, is an unqualified success. Love and Other Drugs may be the most honest romance to grace the screens during all of 2010.
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San Francisco Chronicle

By Mick LaSalle
As is appropriate in a well-crafted and meticulous movie, the acting is strong down the line.
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The Hollywood Reporter

By Kirk Honeycutt
In the end, this is a smart movie that could have been smarter. The script feels like it was a draft or so away from total clarity and focus. But the energy of the cast and a dive into an unfamiliar world make the movie rather addictive.
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By Stephanie Zacharek
As potentially appealing as these two actors might be, there's just nowhere for this story to go.
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Philadelphia Inquirer

By Steven Rea
There's no adroitness, no grace in the handling of the pitching emotions - funny, sad, icky - that such a story presents.
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Boston Globe

By Ty Burr
If product proves especially difficult to swallow, take with a grain of salt and three or more alcoholic drinks, or wait until such time as active ingredients Hathaway and Gyllenhaal have been more effectively utilized elsewhere.
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USA Today

By Claudia Puig
Zwick's "Once and Again" and "Thirtysomething" portrayed emotion more honestly than many TV shows of their time. But in Love and Other Drugs, he unevenly weds the satirical and the sentimental.
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New York Daily News

By Elizabeth Weitzman
We never really forget we're watching two highly paid professionals create a cinematic placebo, strong enough to entertain without making a long-term impact. Fortunately, everyone works just hard enough to sell us on the whole thing anyway.
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Entertainment Weekly

By Lisa Schwarzbaum
An old-fashioned romance-and-sickness picture, a publicity-grabbing sex picture, an Apatow-lite horny-boys picture, and a liberal satire on pharmaceutical-industry excesses committed in pursuit of pill sales - all in one.
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Rolling Stone

By Peter Travers
Anne Hathaway and Jake Gyllenhaal are hotties with talent. And they maneuver through the daunting maze of shifting tones and intersecting plots of Love and Other Drugs like the pros they are.
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55 out of 100
Mixed or average reviews
Metascore® based on all critic reviews. Scores range from 0 to 100, with higher scores indicating more favorable reviews.