| Hollywood Foreign Press Association |
The Special Relationship |
Best Supporting Actress in a Series, Miniseries or Motion Picture Made for Television |
2010 |
Nominated |
| Academy of Television Arts and Sciences |
The Special Relationship |
Outstanding Lead Actress in a Miniseries or a Movie |
2010 |
Nominated |
| Independent Spirit Awards |
Synecdoche, New York |
Robert Altman Award |
2008 |
Won |
| New York Film Critics Circle |
The Secret Lives of Dentists |
Best Actress |
2003 |
Won |
| New York Film Critics Circle |
American Splendor |
Best Actress |
2003 |
Won |
| National Society of Film Critics |
The Secret Lives of Dentists |
Best Actress - Runner-up |
2003 |
Won |
| Hollywood Foreign Press Association |
American Splendor |
Best Performance by an Actress in a Supporting Role in a Motion Picture |
2003 |
Nominated |
| Independent Spirit Awards |
The Secret Lives of Dentists |
Best Supporting Actress |
2003 |
Nominated |
| Chicago Film Critics Association |
American Splendor |
Best Actress |
2003 |
Nominated |