As Season Three of Grey's Anatomy gets under way, Meredith (Ellen Pompeo) has only a few fleeting moments to ponder her romantic rendezvous with Derek (Patrick Dempsey) at the end of Season Two before Derek and George (T.R. Knight) are quarantined in the same room by a flu epidemic. In another unresolved issue from the previous season, Izzie (Katherine Heigl) is so devastated by the death of heart patient Denny Duquette that she decides to give up her medical career completely. Elsewhere, the wife (Loretta Devine) of surgery chief Webber (James Pickens Jr.) forces him to choose between the hospital and her; and two of the surgeons look after an infant found in a most unexpected place. This episode is highlighted by an extensive flashback to that wonderful night in 2005 just before the series' regulars began their "tour of duty" at Seattle Grace Hospital. ~ Hal Erickson, Rovi