The revelation that Izzie (Katherine Heigl) once gave up a daughter for adoption is a challenge which George (T. R. Knight) is willing to face, or so he thinks. Down in the dumps over her vacillating relationship with Derek (Patrick Dempsey), Meredith (Ellen Pompeo) must also contend with her stepmother Susan (Mare Willingham). Cristina (Sandra Oh) and Burke (Isaiah Washington) have trouble summoning enthusiasm over their impending marriage as long as Colin (Roger Rees) remains on the scene. Alex (Justin Chambers) is convinced that he has found the family of the beleagured "Jane Doe" (Elizabeth Reaser). And in a lighter moment, Dr. Mark Sloan (Eric Dane) teaches an old dog--namely Dr. Webber (James Pickens Jr.)--a few new tricks. ~ Hal Erickson, All Movie Guide