Burn After Reading
I'll preface this by saying that I am a "non-religious" person, because I can't help but wonder if this movie was intended to be a film about several people indulging in the various "7 deadly sins" and reaping their unfavorable results. Just about every major character went through a lot of self-created misery over, basically, nothing but their own misperceptions of various situations and things.
This film could have easily been titled, "Much Ado About Nothing"...which is what made it hilarious to me at the end. It might make it easier on the viewer to understand that, although the movie does have some funny parts in it, my impression was that the film was created like a joke... the whole film building up to the ridiculous punchline in the very last minutes.
There are some lessons to be learned from this film. Or not. :-)
Addendum: The critic reviews on this site by the LA Times and USA Today do a good job of giving you a sense of what to expect.