A pampered Chihuahua accustomed to the living the good life in glamorous Beverly Hills must rein in her heiress instincts and rely on the kindness of strangers in order to find her way back home after becoming hopelessly lost in Mexico. Chloe (voice of Drew Barrymore) is a diamond-clad toy dog who favors traveling in her wealthy owner's purse over frolicking in an open park, and Papi (voice of George Lopez) is the kind of independent pup that she doesn't afford a second glance. When a vacation mishap leaves Chloe stranded in Mexico, the Chihuahua who doesn't speak a lick of Spanish must rely on street-smart German shepherd Delgado (voice of Andy Garcia) to guide her back home before she wanders any further south. Meanwhile, brave Papi races to the border intent on proving his love for Chloe by tracking her down and escorting her home in style. Along the way, Papi is joined by an enthusiastic pack of helpful pooches (voices of Luis Guzman, Plácido Domingo, and Eddie "Piolin" Sotelo) a pair of concerned humans (Piper Perabo and Manolo Cardona), an anxious iguana (voice of Paul Rodriguez), and a crafty rat (voice of Cheech Marin). ~ Jason Buchanan, Rovi